A series of discoveries spanning the last decade has challenged our view of microglia, the brain’s innate immune cells, showing their essential but previously unexpected contribution to the remodelling of neuronal circuits. In this emergent field of investigation, research in Dr. Marie-Eve Tremblay’s laboratory at the Division of Medical Sciences, University of Victoria, aims to determine how this newly-defined mechanism could be implicated in the loss of neuronal connections that best correlates with the impairment of learning and memory across major depression, schizophrenia, aging, and neurodegenerative diseases.
The goal of our research is to design novel therapeutic strategies that specifically target microglia to promote brain resilience and healthy cognitive functions along the aging trajectory. We thereby aim to prevent and treat major depressive disorder, schizophrenia, and the highly prevalent sporadic forms of neurodegenerative diseases including Parkinson’s and Alzheimer’s disease.
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Carrier et al. (2024) Iscience: Bone marrow-derived myeloid cells transiently colonize the brain during postnatal development and interact with glutamatergic synapses
Bobotis et al. (2024) Frontiers in Cellular Neuroscience: Established and emerging techniques for the study of microglia: visualization, depletion, and fate mapping
Carrier et al. (2024) Brain, Behavior, Immunity: Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge